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Scientists Create the World's Largest Brain Map
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2,929,485 Views • Apr 22, 2025 • Click to toggle off description
Scientists have created the first precise 3D map of a mouse brain showing over 500 million synapses and 200,000 cells all within a 1 mm cube of brain. The scientists behind this feat hope it will eventually shed light on how human brains store visual memories.

Announcement: www.nature.com/immersive/d42859-025-00001-w/index.…

Paper: www.nature.com/articles/s41586-025-08790-w

#brain #breakthrough #science #shorts

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RYD date created : 2025-05-04T13:34:13.478322Z
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2,377 Comments

Top Comments of this video!! :3

@DrBenMiles

1 week ago

What are we going to do tonight, Brain?
Same thing we do every night, Pinky.

4.2K | 50

@jaha9329

1 week ago

-What have you done?
-I've mapped a mouse.
-How did you do that?
-I've used the mouse.

14K | 21

@ars-br1ms

1 week ago

it's insane that stitching together all of those images took longer than that mouse lived for, brain is the craziest organ by far

4.4K | 53

@BestofYouTubeHD

1 week ago

A brain is learning about a brain!

19K | 102

@SnailMan63

1 week ago

What I love about science is that we’ll always be on the beginning of new, exciting things because when we figure out one thing we discover a new question to be answered

896 | 2

@Barely_Evolved_Cognition

1 week ago

You forget why you're there after wandering into the kitchen because your Working Memory has dumped its buffer of old items to add new items. This typically happens when you aren't staying focussed on your task, so the brain will judge that any memories related to your previous task has a lower priority to new information: such as whatever you just looked at when entering the kitchen & the cascade of memories that seeing it has pulled out of your medium/long-term memory.

3 | 0

@Justin3dprints

1 week ago

Just a heads-up: That coffee we gave you earlier had fluorescent calcium in it so we can track the neuronal activity in your brain. There's a slight chance the calcium could harden and vitrify your frontal lobe. Anyway, don't stress yourself thinking about it. I'm serious. Visualizing the scenario while under stress actually triggers the reaction. -- cave johnson 1957

4.6K | 31

@Shlooomth

1 week ago

Holy crap that’s how dense neurons and their connections are.

4.1K | 30

@SpartanVirus

1 week ago

0.2% of the mouse brain took 5 years to map. And their next goal is to map... let's see, here... oh yes, 99.8%...

2.4K | 38

@meridianheights6255

1 week ago

This is one of those rare, awesome shorts. Well done.

9 | 0

@bronzejourney5784

1 week ago

Thats way more congested and densely packed than i have ever imagined it.

Explains quite a few things actually. Honestly, nature/evolution did a bang-up job as a designer. We should take the reins as soon as possible. As a biotech major i like to think im doing my part.

40 | 4

@sjonesie1

1 week ago

I love how enthralled the mouse was with Tom & Jerry.

938 | 8

@thelizard7609

1 week ago

Can you please give us all the link to the published version of this experiment as well

205 | 2

@bligabliga

1 week ago

opens fridge*

"why did i come in here again?"

begins years of brain research*

1.1K | 8

@ae_unal

1 week ago

Currently we are trying to find out how can we compress this data without losing information before mapping the whole brain. It has an enormous size but every small detail is important. We discussed this with Allan institute previous year, it is cool seeing the project here.

6 | 0

@SoirEkim

1 week ago

I have this feeling that our brains have another level of neurological communication outside chemical, electrical or physical interactions. This feeling is born from the knowledge that a subject can slip on a cap wired with sensors which detect signals from the brain as it operates. What’s to say that neurons are not able to pick up signals much like the sensor cap? Can a neuron detect a signal like the sensor cap from a neuron on the other side of the brain? Let’s call that a bit. How many links can be made from one neuron to all the others in this way? If they all do this the computational complexity would be off the charts. However as highly unlikely as this may be I still feel like there might be something to this idea…

7 | 0

@AgentSapphire

1 week ago

Very Oversimplified:

The "walking into the kitchen and forgetting what you were doing" is called the doorway effect and its a glitch that happens due to the way our brains are set up.

Our short term memory is designed to throw out information when it no longer becomes relevant. So, for example, you're not still thinking about the pretty butterfly you saw outside your breakfast at mealtime when you arrive at school or at work. You're in a new place with new expectations. Its what allows us to change our focus to new things.

Our brains do this by dumping all non essential information when we move onto something "new". And because doorways are the dividing paths between rooms you are moving from an old room to a new one. So sometimes your brain dumps part of your short term memory because it was information you picked up in the old room. And now you're in the new room. This is also why turning around and quickly returning to the first room can bring the memory back sometimes. Because your brain isn't done getting rid of it and can recall and rebuild the memory.

Edit: As some have pointed out yes, this is still a theory. But it's the best educated guess we have at this moment because we don't fully understand it but we know we're in the right ballpark. It's the same way that gravity is a theory. We don't fully understand it yet, but parts we know are true in certain situations.

Edit2: And because people in the comments are being extremely pedantic with how I phrased my words, yes, I understand the difference between "substantiated theory" and "educated guess" and am taking linguistic liberties so that I can be more clear for the less scientifically inclined everyman as opposed to trying to be as accurate as possible (as the human brain and memory is extremely complex) in an explanation that is intended to be very simplified.

1.3K | 58

@criscat1750

1 week ago

Fun fact: the reason we forget things when we walk into a new room is cause its a survival mechanism, that helps us stay focused and take in the new environment to watch out for predators or any dangers.

510 | 11

@miketaylor6869

1 week ago

As a materials engineer working almost every day with an SEM (Scanning Electron Microscope), I believe there are far more effective ways to scan a mouse’s brain than slicing it into 25,000 sections and scanning each one. You could achieve similar results in a fraction of the time probably around 1% of the time it took them using a Transmission Electron Microscope (TEM).

Additionally, there are other approaches. For instance, a powerful enough CT scan (Computed Tomography) could map the entire brain, and with AI-assisted reconstruction, you could generate a full 3D volume.

Finally, if slicing is still the preferred method for that level of detail, an AFM (Atomic Force Microscope) would likely be a better choice.

In conclusion, I think it ultimately comes down to funding. Equipment like this is typically reserved for high-tech industrial applications, while fundamental research projects like mapping a mouse’s brain are, unfortunately, often underfunded.

125 | 10

@diobrando5974

5 days ago

As someone who works with electron microscopes, I’m surprised they were able to scan brain cells at all. TEM is notorious for destroying the sample after scanning. The electrons move at 0.5c; the heavy damage is to be expected.

| 0

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